Research and Development
Zeria Group’s Research and Development
Zeria is promoting efficient and steady new drug development in Japan and overseas that includes actively allocating management resources to R&D and undertaking global clinical trials.
Ethical Drug Development
Zeria has built a pipeline focused on the gastrointestinal field and launched numerous pharmaceutical products throughout the world, including Acofide, an original first-in-class therapeutic agent discovered and developed by Zeria for functional dyspepsia.
Additionally, we are actively in-licensing and developing drugs that have sales track records in overseas markets with the aim of contributing to medical care.
Swiss-based Tillotts Pharma, a Zeria Group company and the originator of the ulcerative colitis therapeutic agent Asacol, is carrying out business centering on lower gastrointestinal tract treatments. Tillotts Pharma also proactively undertakes clinical development to raise the added value of products, which includes developing improved-version mesalazine formulations utilizing new formulation technologies and adding new dosage forms.
Additionally, we are actively in-licensing and developing drugs that have sales track records in overseas markets with the aim of contributing to medical care.
Swiss-based Tillotts Pharma, a Zeria Group company and the originator of the ulcerative colitis therapeutic agent Asacol, is carrying out business centering on lower gastrointestinal tract treatments. Tillotts Pharma also proactively undertakes clinical development to raise the added value of products, which includes developing improved-version mesalazine formulations utilizing new formulation technologies and adding new dosage forms.
Aiming for Efficient Global Development
In 2018 Zeria and Tillotts Pharma built a new organization that unifies the management of R&D at both companies, with the aim of achieving efficient global development.
The management under this new organization will control the Zeria Group’s global development, thereby enabling the Group to strengthen its new drug pipeline. The Zeria Group aims to raise its global R&D capabilities to steadily provide treatments as quickly to possible to patients fighting illnesses.
The management under this new organization will control the Zeria Group’s global development, thereby enabling the Group to strengthen its new drug pipeline. The Zeria Group aims to raise its global R&D capabilities to steadily provide treatments as quickly to possible to patients fighting illnesses.
Developing Consumer Healthcare Products that Satisfy Customer Needs
Consumer Healthcare product development aims at developing products that match customer needs in a broad range of categories. These include OTC drugs that contribute to self-medication as well as quasi-drugs, cosmetics, health foods and medical devices that support extended healthy lifespans.
Research and Development Pipeline
UP DATE 1-Aug-2024
1. Domestic
Stage | Development Code/ Generic Name |
Development | Indications | Classsification | Origin |
NDA filed | ZG-801 Patiromer Sorbitex Calcium |
Zeria | Hyperkalemia | Potassium binder | In-licensed |
Phase III | Z-338 Acotiamide |
Zeria | Pediatric functional dyspepsia | Upper gastrointestinal motility modulator | Original |
Phase II | ZG-802 Acotiamide |
Zeria | Underactive bladder | Lower urinary tract function modulator | Original |
Phase II*(Investigator-Initiated Trial) | Z-338 Acotiamide |
Kyushu University | Esophagogastric junction outflow obstruction | Upper gastrointestinal motility modulator | Original |
*: Supported by a grant from Japan Agency for Medical Research and Development (AMED)
2. Overseas
Stage | Development Code/ Generic Name |
Development | Indications | Classsification | Origin |
NDA approved (Honduras, Dominican Republic, Ecuador, Chile, El Salvador, Peru) |
Z-338 Acotiamide |
Faes Farma | Functional dyspepsia | Upper gastrointestinal motility modulator | Original (Out-licensed) |
NDA approved (Thailand) |
Z-338 Acotiamide |
Meiji Seika Pharma | Functional dyspepsia | Upper gastrointestinal motility modulator | Original (Out-licensed) |
NDA filed (Vietnam) |
Z-338 Acotiamide |
Pharmaceutical Joint Stock Company of February 3rd | Functional dyspepsia | Upper gastrointestinal motility modulator | Original |
NDA filed (Singapore) |
Z-338 Acotiamide |
United Italian Trading Corporation Pte. Ltd. | Functional dyspepsia | Upper gastrointestinal motility modulator | Original (Out-licensed) |
NDA filed (Colombia, Costa Rica, Guatemala, Panama, Nicaragua) |
Z-338 Acotiamide |
Faes Farma | Functional dyspepsia | Upper gastrointestinal motility modulator | Original (Out-licensed) |
Phase III (Europe, United States, Canada) |
Z-338 Acotiamide |
Agastra-Lab s.r.l. | Functional dyspepsia | Upper gastrointestinal motility modulator | Original (Out-licensed) |
Launched
Launch Date | Development Code/ Generic Name |
Development | Indications | Classification | Origin |
October 2023 (Mexico) |
Z-338 Acotiamide |
Faes Farma | Functional dyspepsia | Upper gastrointestinal motility modulator | Original (Out-licensed) |